中间体 - 安徽贝克联合制药有限公司
产品中心 产品中心

中间体

发布日期:2019-11-07 浏览次数:984

Intermediates List
Usage
Product
CAS No.
Documentation
 Lamivudine
L-Menthyl glyoxylate monohydrate (L-MGH)
 111969-64-3
 Technical Package
(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (HME)
 147126-62-3
 Technical Package
(2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (CME)
 147027-10-9
 DMF/US FDA
(2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]- 2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate)
 173522-96-8
 Technical Package
 Ritonavir
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT)
 144163-97-3
 Technical Package
N-[2-Isopropylthiazol-4-ylmethyl (methyl)-carbamoyl]-L-valine
(MTV-III)
 154212-61-0
 Technical Package
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2 succinate salt (BDH succinate salt)
 183388-64-9
 Technical Package
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH PURE)
 144163-85-9
 Technical Package
 Cobicistat
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT)
 144163-97-3
 Technical Package
2-Isopropyl-4(((N- Methyl)amino) methyl)thiazole Dihydrochloride (MTV 2HCl)
 1185167-55-8
 Technical Package
 Entecavir
(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)-diphenylmethyl] amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl) cyclopentanol (Ent-V)
 142217-78-5
 Technical Package
6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (Ent-VII)
 142217-80-9
 Technical Package
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)- 2-methylenecyclopentyl]-6H-
purin-6-one (Ent-VIII)
 142217-81-0
 Technical Package
 Emtricitabine
(2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl-1-yl)-[1,3] oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (FCME)
 764659-72-5
 Technical Package
 Tenofovir
 Disoproxil
 Fumarate
(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA)
 147127-20-6
 Technical Package

 Bedaquiline

 Fumarate

3-Benzyl-6-bromo-2-methoxyquinoline (BBMQ)
 654655-69-3
 --
3-Dimethylamino-1-(naphthalen-1-yl) propan-1-one hydrochloride (DMNP)
 5409-58-5
 --
 Lopinavir
N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide 5-oxopyrrolidine-2-carboxylic acid (THP)
 192726-06-0
 --
 Tenofovir

 Alafenamide

 Fumarate

(S)-Isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)-phosphoryl)amino)propanoate (TA)
 379270-37-8
 --
9-[(R)-2-(phenylphosphonomethoxy) propyl]adenine (PPMPA)
 379270-35-6
 --
 Dolutegravir
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
 1335210-34-8
 --
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
 1335210-35-9
 --

 Selegiline

 Hydrochloride

N,N-dimethyl-N'-(1-phenylpropan-2-yl)-Sulfamide
 1875882-12-4
 --
(2R)-1-phenyl-N-prop-2-ynylpropan-2-amine hydrochloride
 115586-38-4
 --
R-(-)-N-Demethyl Deprenyl
 56862-28-3
 --
R & D List
 Abacavir Sulfate
(1R,4S)-4-amino-2-Cyclopentene-1-methanol hydrochloride
 287717-44-6
 --
2-amino-4,6-dichloro-5-formamidopyrimidine
 171887-03-9
 --
 Obeticholic Acid
3alpha-Hydroxy-7-oxo-5beta-cholic acid
 4651-67-6
 --
Methyl 7-keto-3alpha-hydroxy-5beta-cholanoate
 10538-59-7
 --
(R)-methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
 336099-76-4
 --
(R)-methyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
 1516887-31-2
(R)-methyl 4-((3R,6S)-6-ethyl-hexadecahydro-3-hydroxy-10,13-dimethyl-7-oxo-1H-cyclopental[a]phenanthren-17-yl)pentanoate
 1654780-32-1
(3alpha,5beta,6alpha)-6-Ethyl-3-hydroxy-7-oxocholan-24-oic acid
 915038-26-5
 --
 Rilpivirine
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile
 189956-45-4
 --
4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile
 244768-32-9
4-Iodo-2,6-dimethylaniline
 4102-53-8
 --
3-(4-amino-3,5-dimethylphenyl)prop-2-enamide
 500292-92-2
(E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride
 661489-23-2
 --
* Patent-protected area, not to be sold.
www.bcpharm.com / info@bcpharm.com / WeChat: bcpharm

Intermediates List
Usage
Product
CAS No.
Documentation
Lamivudine
L-Menthyl glyoxylate monohydrate (L-MGH)
111969-64-3
Technical Package
(2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (HME)
147126-62-3
Technical Package
(2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester (CME)
147027-10-9
DMF/US FDA
(2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]- 2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate)
173522-96-8
Technical Package
Ritonavir
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT)
144163-97-3
Technical Package
N-[2-Isopropylthiazol-4-ylmethyl (methyl)-carbamoyl]-L-valine
(MTV-III)
154212-61-0
Technical Package
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2 succinate salt (BDH succinate salt)
183388-64-9
Technical Package
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH PURE)
144163-85-9
Technical Package
Cobicistat
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate (NCT)
144163-97-3
Technical Package
2-Isopropyl-4(((N- Methyl)amino) methyl)thiazole Dihydrochloride (MTV 2HCl)
1185167-55-8
Technical Package
Entecavir
(2R,3S,5S)-3-(Benzyloxy)-5-[2-[[(4-methoxyphenyl)-diphenylmethyl] amino]-6-(phenylmethoxy)-9H-purin-9-yl]-2-(benzyloxymethyl) cyclopentanol (Ent-V)
142217-78-5
Technical Package
6-(Benzyloxy)-9-((1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (Ent-VII)
142217-80-9
Technical Package
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)- 2-methylenecyclopentyl]-6H-
purin-6-one (Ent-VIII)
142217-81-0
Technical Package
Emtricitabine
(2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl-1-yl)-[1,3] oxathiolane-2-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester (FCME)
764659-72-5
Technical Package
Tenofovir
Disoproxil
Fumarate
(R)-9-[2-(Phosphonomethoxy)propyl]adenine (PMPA)
147127-20-6
Technical Package

Bedaquiline

Fumarate

3-Benzyl-6-bromo-2-methoxyquinoline (BBMQ)
654655-69-3
 --
3-Dimethylamino-1-(naphthalen-1-yl) propan-1-one hydrochloride (DMNP)
5409-58-5
 --
Lopinavir
N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide 5-oxopyrrolidine-2-carboxylic acid (THP)
192726-06-0
 --
Tenofovir

Alafenamide

Fumarate

(S)-Isopropyl-2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)-phosphoryl)amino)propanoate (TA)
379270-37-8
 --
9-[(R)-2-(phenylphosphonomethoxy) propyl]adenine (PPMPA)
379270-35-6
 --
Dolutegravir
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
1335210-34-8
 --
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
1335210-35-9
 --

Selegiline

Hydrochloride

N,N-dimethyl-N'-(1-phenylpropan-2-yl)-Sulfamide
1875882-12-4
 --
(2R)-1-phenyl-N-prop-2-ynylpropan-2-amine hydrochloride
115586-38-4
 --
R-(-)-N-Demethyl Deprenyl
56862-28-3
 --
R & D List
Abacavir Sulfate
(1R,4S)-4-amino-2-Cyclopentene-1-methanol hydrochloride
287717-44-6
 --
2-amino-4,6-dichloro-5-formamidopyrimidine
171887-03-9
 --
Obeticholic Acid
3alpha-Hydroxy-7-oxo-5beta-cholic acid
4651-67-6
 --
Methyl 7-keto-3alpha-hydroxy-5beta-cholanoate
10538-59-7
 --
(R)-methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-(tert-butyldimethylsilyloxy)-10,13-dimethyl-7-oxo-hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
336099-76-4
 --
(R)-methyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
1516887-31-2
(R)-methyl 4-((3R,6S)-6-ethyl-hexadecahydro-3-hydroxy-10,13-dimethyl-7-oxo-1H-cyclopental[a]phenanthren-17-yl)pentanoate
1654780-32-1
(3alpha,5beta,6alpha)-6-Ethyl-3-hydroxy-7-oxocholan-24-oic acid
915038-26-5
 --
Rilpivirine
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile
189956-45-4
 --
4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile
244768-32-9
4-Iodo-2,6-dimethylaniline
4102-53-8
 --
3-(4-amino-3,5-dimethylphenyl)prop-2-enamide
500292-92-2
(E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride
661489-23-2
 --
* Patent-protected area, not to be sold.
www.bcpharm.com / info@bcpharm.com / WeChat: bcpharm